Botulinum toxin therapy has emerged as a pivotal treatment in the management of spasticity, a debilitating neuromuscular condition characterised by increased muscle tone and hyperactive reflexes. By ...

Antibody administration following saline or BTX administration at the beginning of the treatment. Anti-IGF1R antibody treatment is denoted as IGF1R and control IgG antibody treatment as control IgG.

PHOENIX -- Botulinum toxin injections offered relief from sialorrhea, or excessive saliva production, in patients with amyotrophic lateral sclerosis (ALS), according to a small study. The ...

In a comprehensive research study, scientists have uncovered a previously unknown mechanism explaining how neurons survive botulinum neurotoxin type A (BoNT/A) exposure, despite the toxin's powerful ...

Botulinum toxin (BoNT), often referred to as a “miracle poison,” is one of the deadliest biological substances known to man. 1 BoNT is a neurotoxin produced by Clostridium botulinum. A rod-shaped ...

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A single series of intrarectal botulinum toxin type A injections may provide significant improvement in fecal incontinence symptoms. Submucosal intrarectal injections of botulinum toxin type A (BoNTA) ...

Two research groups have designed chimeric fusion proteins that constitute a new “trojan horse” approach to neutralize lethal botulinum toxins. Botulinum neurotoxins (BoNTs)—a family of bacterial ...

Early preclinical work led by researchers from Harvard Medical School has found certain elements in a toxin produced by the anthrax bacterium can silence activity in pain-signaling brain neurons. The ...

Currently there's no treatment for botulism once the toxin gets into neurons. This novel treatment neutralized the toxin with a second, modified botulinum toxin that delivered a mini antibody into the ...