Exactly how does the DNA replication process start? USC scientists provide the first snapshot of how double-helix DNA begins to unwind and replicate after certain proteins put on the “squeeze.” A ring ...

Cold Spring Harbor, NY - It's a good thing we don't have to think about putting all the necessary pieces in place when one of our trillions of cells needs to duplicate its DNA and then divide to ...

Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. Scientists have determined at atomic resolution the structure of machinery that ...

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...