Most inborn errors of immunity (IEIs) are caused by defects that arise somewhere along the developmental path between hematopoietic stem cells (HSCs) and mature immune cells. Replacement of mutant ...
Like their causative mutations, pathophysiology and natural history, the clinical presentation of inborn errors of immunity (IEI) varies widely. Nevertheless, some features, above all recurrent and/or ...
Chimeric antigen receptor T (CAR-T) cell therapy has emerged as a transformative approach in modern medicine, demonstrating remarkable efficacy in targeting pathogenic B-cell lineages with ...
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