Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

The upsets continued into the early window of games on Sunday, with the most notable being the Panthers forcing three turnovers against NFL MVP front-runner Matthew Stafford and shocking the Rams, 31-28. The Texans also took down the Colts, further clogging up the AFC South standings with five weeks to play.

The Cleveland Browns hosted the Buffalo Bills in Week 16. Here's how rookie quarterback Shedeur Sanders performed against Buffalo.

Starting off the second half with the football, the Browns offense was able to finally get the ball down the field and put points on the board. Cleveland kicker Andre Szmyt would convert on a 50-yard field goal to end Chicago's hopes of pitching a shutout in this game.

The Steelers took over first place in the AFC North by surviving the Ravens after an overturned touchdown in the final minutes. The Jaguars remain atop the AFC South after dismantling the Colts, who lost Daniel Jones to an Achilles injury. And the Bills all but dashed the Bengals' playoff hopes with a 39-34 win in the snow.

CLEVELAND - This was supposed to be an easy Sunday afternoon for the Buffalo Bills, a team headed to the playoffs facing a 3-11 Cleveland Browns team that can’t wait for yet another horrible season to end.

Sunday marks the beginning of a holiday week here in the United States. But before we can turn our collective attention to turkey, stuffing, and time with family, we need to work through another Sunday slate of NFL action. Week 12 got underway with the ...