A novel Raman technique measures protein–ligand binding at physiologically relevant conditions in real time. Researchers at the Texas Agricultural and Mechanical University (TX, USA) have developed a ...

Recently, SandboxAQ launched what it claims is the largest publicly available dataset of protein-ligand pairs with annotated experimental binding potency data. According to the company, the ...

Raman spectroscopy - a chemical analysis method that shines monochromatic light onto a sample and records the scattered light that emerges - has caused frustration among biomedical researchers for ...

Scientists have revealed the effect of temperature on water in protein-ligand interactions, providing a way to produce structures for drug discovery that are less biased by freezing artifacts.

Researchers have discovered how unstructured segments of surface proteins regulate the biological function of a cell. Their ...

An interdisciplinary research team of the Institutes of Physical Chemistry and Physics of the University of Freiburg and the Max Planck Institute of Biophysics in Frankfurt-am-Main has discovered a ...

Tumor necrosis factor ligand superfamily member 9 (4-1BBL), also known as 4-1BB ligand, CD137L, or TNFSF9, is a cytokine that binds to TNFRSF9. It serves as the high-affinity ligand for 4-1BB and ...

Cancer immunotherapies, anti-cancer treatments that target a patient’s own immune system, working to make it more effective, have revolutionized the | Cancer ...

(Memphis, Tenn.—June 7, 2022) Cryogenic (frozen) protein structures are central to understanding function and developing drugs. Scientists at St. Jude Children’s Research Hospital have created an ...