Jonathan Taylor and the Indianapolis Colts came up short on Monday night, suffering defeat against a red-hot San Francisco 49ers side. The Colts put up a respectable fight, but they just couldn’t compete with the Niners, who have now stacked up five straight victories.

Nelson is also the second offensive lineman in NFL history to be named to the Pro Bowl in his first eight seasons, joining legendary Cleveland left tackle Joe Thomas and putting himself on a track to earn a Hall of Fame nod at some point down the line.

With Philip Rivers expected to get his second start of the season, the Colts' offense will likely run through the legs of Jonathan Taylor once again. The sixth-year back had been leading the league in rushing yards for most of the season, but on Monday, Taylor will not take the field as the rushing leader.

Both Indianapolis Colts star running back Jonathan Taylor and head coach Shane Steichen feel Philip Rivers has provided their team with "juice" by coming out of retirement to join them for the last four games of the 2025 NFL season.

San Francisco 49ers quarterback Brock Purdy completes a 17-yard pass to wide receiver Jauan Jennings. San Francisco 49ers running back Christian McCaffery bolts out of the backfield for a 24-yard gain.

Two Indianapolis Colts players were selected to represent the AFC at the 2026 Pro Bowl Games, including running back Jonathan Taylor and left guard Quenton Nelson.

Week 17 of the fantasy football season has arrived, which means your fantasy season has boiled down to one final lineup decision… or 12 of them, depending on how much second-guessing you’ve done since Tuesday.

Christian McCaffrey and Jonathan Taylor shared a moment on Monday night that resonated far beyond the final score. In a league driven by competition, the respect between two elite running backs became one of the night’s lasting images in an NFL game between the Indianapolis Colts and San Francisco 49ers.