Maintaining muscle mass is crucial for health, and researchers have identified the protein BCL6 as vital for this. Studies reveal GLP-1 medications for weight loss can cause muscle loss ...

A protein called B cell lymphoma 6 (BCL6) could be key to maintaining healthy muscle mass, and potentially could be used to combat muscle wasting conditions in humans, a study in mice suggests.

Scientists have just uncovered something incredible about a protein called BCL6 that could change everything we know about weight loss. Their research shows this protein plays a crucial role in ...

BCL6 is a regulator of SOCS2, so less BCL6 leads to less SOCS2. At normal levels, this allows BCL6 to control how much SOCS2 is expressed, and therefore, how much IGF1 is made.

FIGURE 2. Overview of mTOR signaling pathway. mTOR exists in two complexes mTORC1 and mTORC2. Multiple factors, including glucose, amino acids and growth factors can induce mTORC1 activity through ...

Rapamycin is mTORC1 inhibitor, but long-term exposure to rapamycin (>18 hours) could also inhibit mTORC2. RhoA signaling pathway is regulated through the mTORC2 pathway; thus we hypothesized that long ...

Ferroptosis, a novel type of regulated cell death mediated by iron-dependent lipid oxidation, was discovered a decade ago. Significant progress has been made in our knowledge of ferroptosis and immune ...

Conclusions Our findings indicate that Wnt16 activates PCP/JNK and crosstalks with mTORC1-PTHrP pathway to inhibit chondrocyte hypertrophy. Our preclinical study suggests that Wnt16 may be a potential ...