SciELO10d
The Effect of long-term rapamycin administration on intracellular calcium quantification and RhoA activity in kainic acid epilepsy model
Rapamycin is mTORC1 inhibitor, but long-term exposure to rapamycin (>18 hours) could also inhibit mTORC2. RhoA signaling pathway is regulated through the mTORC2 pathway; thus we hypothesized that long ...
Rolling Out17d
7 ways this protein could transform weight loss forever
Scientists have just uncovered something incredible about a protein called BCL6 that could change everything we know about weight loss. Their research shows this protein plays a crucial role in ...
Indiatimes18d
This protein can help healthy weight loss by keeping muscle mass intact
Maintaining muscle mass is crucial for health, and researchers have identified the protein BCL6 as vital for this. Studies reveal GLP-1 medications for weight loss can cause muscle loss ...
Frontiers26d
Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China Background: Tanshinlactone is a compound derived from the herb Salvia ...
eLife1mon
Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway
The strong shear stress altered the membrane lipid microdomain structure of endocardial cells, which activated mTORC2 and PKC and promoted Notch1 cleavage even in the absence of strong ligand ...