precisionmedicineonline1d
More Precise Response Markers Needed for Enhertu Amid HER2 Biomarker Disruption, Researchers Say
By analyzing ERBB2 mRNA expression data, researchers identified a group of HER2-negative patients with poor outcomes and potential markers of treatment resistance.
BioPharma Dive4d
The role of diagnostics in advancing antibody-drug conjugates
From preclinical research to regulatory approval and clinical adoption, diagnostic testing underpins every stage of ADC ...
Targeted Oncology9d
FDA Expands PATHWAY HER2 (4B5) Test to Include HER2-Ultralow Status
The PATHWAY HER2 (4B5) test is now FDA-approved to assess HER2-ultralow status in metastatic breast cancer, expanding its ...
oncnursingnews9d
T-DXd Companion Diagnostic in HER2-Ultralow Metastatic Breast Cancer Gains FDA Approval
The FDA has approved a companion diagnostic to determine if patients with HR-positive, HER2-ultralow metastatic breast cancer ...
EuropaWire14d
Roche Expands FDA Approval of PATHWAY® HER2 Test for HER2-Ultralow Breast Cancer Status
Roche has announced that the FDA has expanded the approval of its PATHWAY® HER2/neu (4B5) Rabbit Monoclonal Primary Antibody test to identify HE ...
The Express Tribune14d
5 IHC judges seek to preempt 'usurpation of judicial norms'
In an unusual development, five judges of the Islamabad High Court (IHC) have approached the chief justice of Pakistan and three high court chief justices, requesting them not to advise the ...
Kauppalehti14d
Roche receives FDA approval for the first companion diagnostic to identify patients with HER2-ultralow metastatic breast cancer eligible for ENHERTU
As seen in the DESTINY-Breast06 trial, a pproximately 20-25 percent of hormone receptor (HR)-positive, HER2-negative breast cancer patients may be considered HER2-ultralow.1 These patients may now be ...
The Express Tribune15d
IHC summons AGP in missing persons case
A larger bench of the Islamabad High Court (IHC) on Thursday summoned the attorney general for Pakistan (AGP) on March 6 in a case relating to the missing persons, saying that there was no ...
TechRepublic17d
Top 8 Penetration Testing Tools to Enhance Your Security
One of the ways in which security professionals can assess the security posture of an entire digital ecosystem is by carrying out penetration testing, or pen testing for short. Penetration testing ...
Frontiers18d
Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry
The IHC validation on human knee joint specimens confirmed the ... The P-value represents the probability of obtaining a test statistic as extreme as, or more extreme than, the observed result under ...
Nasdaq18d
FDA Approves AstraZeneca And Daiichi Sankyo's ENHERTU For HER2-Low/Ultralow Breast Cancer
(RTTNews) - The U.S. Food and Drug Administration has approved AstraZeneca Plc. (AZN.L, AZN) and Daiichi Sankyo's (DSKYF.PK) ENHERTU (fam-trastuzumab deruxtecan-nxki) for the treatment of adult ...
PharmiWeb18d
Enhertu approved in the US as first HER2-directed…
The approval also highlights the importance of testing metastatic breast cancer tumours for detectable staining with a standard IHC test to identify those who may be eligible for treatment with ...