IFLScience3d
Plants Have Given Us Crucial Lifesaving Drugs – And Now We Risk Losing Them
These drugs, discovered decades ago, continue to save lives today, but more recent research has led to the development of ...
Frontiers12d
Barnacle inspired high-strength hydrogel for adhesive
Therefore, the mechanical properties of gel become stronger and the modulus increases. After soaking in acid, alkali, SDS and guanidine thiocyanate solutions, the mechanical properties of PMAA/PEI gel ...
eLife15d
Flexibility in PAM Recognition Expands DNA Targeting in xCas9
The FES is plotted along the distances between the R1335 guanidine and either the E1219 carboxylic group (CV1) or the G3 nucleobase (CV2, details in Materials and Methods). A well-defined minimum ...
Frontiers12d
Technical Validation and Clinical Utility of an NGS Targeted Panel to Improve Molecular Characterization of Pediatric Acute Leukemia
RNA was manually extracted using guanidine thiocyanate-phenol-chloroform method (TriPure, Roche Diagnostics, United States), or using column-based methods with Direct-zol RNA MiniPrep (Zymo Research, ...
Nature12d
TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice
Abnormal accumulation of the amyloid-β peptide (Aβ) in the brain appears crucial to pathogenesis in all forms of Alzheimer disease (AD), but the underlying mechanisms in the sporadic forms of AD ...
C&EN29d
Transformation-Guided Genome Mining Provides Access to Brominated Lanthipeptides
Department of Chemistry, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana−Champaign, ...
C&EN26d
N-Branched Tricyclic Guanidines as Novel Melanocortin-3 Receptor Agonists and Melanocortin-4 Receptor Antagonists
Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, 3300 S. University Dr., Fort Lauderdale, Florida 33328, United States Department of Pharmacology and Physiology, Georgetown ...