(p)ppGpp, through its interaction with RNA polymerase, aids in managing replication conflicts and facilitates the loading of ...

Solving a 30-year mystery Boulton became interested in dynamic single-molecule analysis when studying RAD51 — an enzyme regulated by BRCA2 to repair double-strand DNA breaks. Multiple RAD51 ...

then slides along it until it reaches the region of single-stranded DNA at the damaged site in need of repair 3. Once BRCA2 reached the damage, the researchers, using the C-Trap, could observe the ...

The team initially set out to study another replication machinery protein, single-stranded DNA-binding protein ... whether the enzymatic period was during exonuclease repair or DNA extension. “This ...

PARP1 is critical for repairing DNA single-strand breaks. First-generation PARP1/2 inhibitors have proven effective in the treatment of tumors with mutations in the essential homologous recombination ...

The damage in question is the DNA double-strand break ... has the unique ability to visualize the behavior of DNA repair proteins on a single DNA molecule in real time. They show in this study ...

During DNA replication, the double helix unwinds, and each strand serves as a template for synthesizing ... Cells have evolved various DNA repair mechanisms to correct such mutations. One such ...

Research led by The University of Texas Health Science Center at San Antonio shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes ...