Long-term weight loss for patients with obesity proved mostly successful after taking prescription-only injectable semaglutide, the Cleveland Clinic found. Researchers at the nonprofit academic and research medical center identified key factors that impact the effectiveness of the widely popular medication.

Four key factors can greatly impact how much weight people lose while taking GLP-1 drugs like Ozempic, Wegovy, Victoza, and Saxenda. Here's what to know.

F ROM LOS ANGELES to London, weight-loss drugs such as Ozempic are reshaping culture as much as waistlines. Some Ozempic-takers have tiny appetites and dine at unusual hours to avoid spells of nausea.

In July, the U.S. Food and Drug Administration warned that people are overdosing on compounded semaglutide injectable products.

Many people are doing an end-run around their doctor's office, reaching out to potentially unreliable sources that promise to set them up with Wegovy, Zepbound and other weight-loss drugs.

"Weight loss medications are not one size fits all and patients should always discuss options with a trusted medical professional," one expert told Newsweek.