Abstract. Background: Gastric cancer is one of the most common malignant tumors worldwide, and the 2nd most common in China. The development of new agents for the treatment of advanced gastric cancer ...

Abstract. Purpose: Radiation therapy continues to be an important therapeutic strategy for providing definitive local/regional control of human cancer. However, oncogenes that harbor driver mutations ...

Abstract. The BCR-ABL1–negative myeloproliferative neoplasms (e.g., essential thrombocythemia, polycythemia vera, and primary myelofibrosis) are a group of heterogeneous hematologic malignancies that ...

Abstract. Purpose: To improve the efficacy and reduce the gastrointestinal toxicity of the cancer prodrug, CPT-11, we have developed immunoconjugates of its active form, SN-38, and an anti-CEACAM5 ...

Abstract. Purpose: The high affinity receptor 1 (NTSR1) and its agonist, neurotensin (NTS), are correlated with tumor cell aggressiveness in most solid tumors. As chemoresistance and tumor ...

AbstractMelanoma is the leading cause of skin cancer–related death. As prognosis of patients with melanoma remains problematic, identification of new therapeutic targets remains essential.

Remarkable progress made against cancer in the United States is reflected by a 33% decline in the overall cancer mortality rate between 1991 and 2020 ().Despite this reduction, 2,001,140 new cases of ...

Ancestral effects have been increasingly investigated over the years in efforts to reduce health disparities (1–3).Multiomic analyses of large-scale datasets such as The Cancer Genome Atlas (TCGA) and ...

2025 Meetings. Abstracts: AACR Special Conference in Cancer Research: Translating Targeted Therapies in Combination with Radiotherapy January 26–29, 2025; San Diego, CA ...

Conditional survival (CS) is defined as the probability of surviving further t years, given that a patient has already survived s years after the diagnosis of a chronic disease.It is the simplest form ...

In the early 1990s, the National Cancer Institute (NCI; Bethesda, MD) introduced a “disease-oriented” drug screening approach using a panel of 60 human cancer cell lines derived from nine different ...

Copper promotes metabolic remodeling in clear cell renal cell carcinoma by enhancing mitochondrial respiration, biosynthesis, and detoxification, fueling tumor progression and offering a target for ...