What is IUI and how does it work? Intrauterine insemination (IUI) is a simple fertility treatment that places washed and prepared sperm directly into the uterus around the time of ovulation. By bypassing the cervix and shortening the sperm’s journey to the egg, it increases the chances of fertilization. The process typically includes: • Monitoring your cycle with ultrasounds and bloodwork • Triggering ovulation with medication (if recommended) • A quick, in-office procedure to place the sperm—us